The A1 will be closed in both directions this weekend while a bridge is taken down.
A 300-tonne crane will demolish the temporary bridge near Catterick.
Highways officials say the work marks another milestone in the completion of the major A1 Leeming to Barton improvement scheme.
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The crane will be positioned on the A1 to carry out the demolition and drivers are advised the road will be closed over the weekend so the work can be carried out safely.
The temporary bridge was put in place in July 2015 to allow space for a new bridge over the A1 and an extra lane to be added to the road as part of the Leeming to Barton major upgrade.
The A1 will be closed in both directions from 8pm on Friday, October 13 until 6am on Sunday, October 15 between junction 51 (Leeming Bar) and Scotch Corner.
The new bridge provides an east west link across the A1, connecting the communities of Catterick Garrison, and Catterick and Brompton.
The bridge will be open to pedestrians, cyclists and equestrians from Monday.
The bridge will open to traffic next month once the road has been resurfaced and other minor work has been carried out.
Highways England project manager Tom Howard said: “This is a significant milestone for the scheme and follows the opening of the southern section last month.
“We need to close the road for safety reasons and we are advising people to plan their journeys, using the many alternative routes that will be signposted off the A1 closure.
“We would like to thank drivers for their patience as we move nearer to completing this vital project.
“When the whole project is complete, the section of the A1 between Leeming and Barton will be upgraded to a three-lane motorway, tackling congestion and improving journey times.”
Drivers who intend to travel on the A1 during the closure are being advised to check the latest traffic conditions before they set off.
Officials say clearly signed diversions will be in place and drivers are advised to allow for an extra 30 minutes to their journey time.
The scheme will be fully open by winter 2017/18. For more details visit the scheme website.