The A66 trans-Pennine route had reopened westbound after being closed for an accident today.
Three cars and a lorry were involved in the incident.
Fire crews from Richmond, Bedale, Ripon and Darlington were called to the scene at about 1.10pm.
Two people were released by firefighters and taken to hospital via road ambulance suffering various injuries.
Crews used small tools, cutting gear, stabalisation equipment, sharps protection, a longboard and a hose reel jet during the incident
The road was shut between Scotch Corner and the A67 turn off for around four hours.