The A684 is to shut for the half term week for roadworks just a month after it closed previously.
North Yorkshire County Council has sent out letters to residents and businesses to say the road will close between Patrick Brompton and Harmby for “further highway maintenance and tree removal” at Akebar.
The work is due to start on October 24 and last five days.
The announcement has angered local businesses.
Richard Warne, who runs the Inspired Chocolate, on Leyburn Business Park, pointed out that it was only a few weeks since they last closed this stretch of road.
“I cannot believe that they would close a key tourism road during the half term holiday week.
“It will bring misery for holiday makers, residents and crucially rural businesses for whom holiday visitors are crucial for survival, especially so in already incredibly challenging times.
“I can only assume the relevant authorities whom planned and approved this are either staggeringly out of touch, or just do not care about the community they serve. We need change, shame on them.”
A council spokesperson said: “The works will be carried out under a full road closure between Patrick Brompton junction and the Harmby junction for a period of five working days.
“Please note that the A684 will be fully closed for this entire period it will not be open to traffic out of hours.”
Advance warning signage advising of the work are to be installed shortly.
The spokesperson added: “Whilst the works are in progress, a fully signed diversion will be in place. On-site personnel will assist in managing access to properties and businesses within the closure.
“Please be advised there may be extended periods when access will not be possible due to the nature of the works and physical constraints of the site. Pedestrian access will be maintained.
“Please note, this work is part of an extensive programme and therefore, some adjustment to this start date or the duration of the works may be necessary should unforeseen circumstances such as significant weather events or emergencies on the highway network arise.
“I would like to take this opportunity to apologise for any disruption that these works may cause and would again request your cooperation to help ensure an efficiently and safely executed project.”