Bird flu has been found in the district, Government officials have confirmed.
Defra said avian influenza H5N1 was confirmed in birds at commercial premises near Leyburn on Friday.
The case is understood to be only the second recorded in the district since the current bird flu outbreak began last October.
A number of cases have been reported in the Northallerton and Thirsk areas.
A Government spokesperson said all birds on the infected premises would be humanely culled.
A temporary control zone covering 3km (1.8 miles) and 10km (6.2 miles) is in place around the site.
There have been 117 confirmed cases of highly pathogenic avian influenza in England since October 1 this year and 251 cases since the H5N1 outbreak started in October 2021.
Defra has ruled that all poultry and captive birds must be housed in England until further notice following an increase in the number of detections of avian influenza in wild birds and on commercial premises.
Bird keepers are required to shut their birds indoors and implement strict biosecurity measures to help protect their flocks from the threat of avian influenza regardless of whatever type or size.
For more details on the restrictions now in place click here.