Department store chain House of Fraser is proposing to close 31 shops including its Binns store in Darlington.
2,000 House of Fraser jobs will be affected, and 4,000 brand and concession roles, if the closure plan gets the go-ahead.
The company said the stores scheduled for closure, which include its flagship London Oxford Street store, will stay open until early 2019.
The retailer needs the approval of 75 per cent of its creditors to go ahead with the plan.
House of Fraser chairman Frank Slevin said: “The retail industry is undergoing fundamental change and House of Fraser urgently needs to adapt to this fast-changing landscape in order to give it a future and allow it to thrive.
“Our legacy store estate has created an unsustainable cost base, which without restructuring, presents an existential threat to the business.”
Closing stores was “a very difficult decision”, he said, but “there should be no doubt that it is absolutely necessary if we are to continue to trade and be competitive”.
The news follows the announcement last month that M&S in Darlington was likely to shut.
The House of Fraser stores identified for closure:
Altrincham, Aylesbury, Birkenhead, Birmingham, Bournemouth, Camberley, Cardiff, Carlisle, Chichester, Cirencester, Cwmbran, Darlington, Doncaster, Edinburgh Frasers, Epsom, Grimsby, High Wycombe, Hull, Leamington Spa, Lincoln, London Oxford Street, London King William Street, Middlesbrough, Milton Keynes, Plymouth, Shrewsbury, Skipton, Swindon, Telford, Wolverhampton, Worcester.