The A66 trans-Pennine route is to remain shut on Sunday and into Monday, officials have said.
The road is shut between Brough and Bowes following heavy snow over the weekend.
Several multi-vehicle accidents were reported on Saturday night, and highways officials have battling to keep it clear on Sunday with drifting snow causing further problems.
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Highways England announced on Sunday evening that the route would stay shut until Monday.
These videos by motorist Gary Bowman show emergency services working to treat injured motorists and free vehicles in blizzard conditions.
Accidents have been reported at Stainmore and Warcop.
A spokesman for Highways England said: “Snow ploughs and gritters are en route to scene to clear the carriageway and the road will be re-opened when safe to do so.
“Diverted traffic should use alternative trans-pennine routes.
“Please allow extra time for your journey and drive to the conditions.
“If possible, delay your journey and only travel if absolutely necessary.”
A Met Office yellow warning remains in place for the district, with snow forecast to continue on Saturday night and into Sunday morning.
In Richmondshire, snow showers are forecast to continue into the afternoon and again this evening.
#A66 the snow gates are closed and carriageway now shut in both directions between the A685 #Brough and the #A67 #Bowes due to heavy snow in the area. We'll keep you updated, but expect the road to remain closed until the worst of the weather passes.
— Highways England (@HighwaysYORKS) March 17, 2018
— Catherine Ainsworth (@CatAinsworth) March 17, 2018
A number of minor roads in the Dales have also been blocked by snow.
— Thomas Beresford (@bezberesford) March 18, 2018